advances in cancer diagnosis and treatment are dramatic
in both hereditary and sporadic cancer.
in BRCA1 and BRCA2, mismatch-repair genes (MLH1,
MSH, MSH6 and PMSH2 and CDH1 are responsible for
several hereditary syndromes including breast ovarian
cancer (HBOC), nonpolyposis colorectal cancer (Lynch)
and diffuse gastric cancer (HDGC). CHEK2*110delC
germline mutation increases by three fold the risk
of breast cancer.
the common sporadic cancer exciting research towards
prediction of prognosis and response to specific
therapies of individuals with cancer is based on: