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GBC |
CURRENT ISSUE: 2009, Volume 8, Number 2 |
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PERSPECTIVE |
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Personalized Molecular cancer-targeted therapy
Why novel causal network-based biomarkers and new targeted agents are needed and how to overcome challenges.
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Anti-VEGF Agents (Bevacizumab) Limitations
What reveal latest high-quality experimental and clinical studies suggesting caution in the clinical use of anti-VEGF agents? Why should oncologists carefully consider these data? more... |
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| Impact of genetics and genomics in breast cancer surgery more... |
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REVOLUTION IN SURGERY |
Laparoscopic & robotic approaches change oncological practice
Improving dramatically quality of life. Butvwhat are the risks? |
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| EDITORIAL: New era in cancer surgical treatment |
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| NEWS & VIEWS: Rectal cancer resection |
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| NEWS & VIEWS: Laparoscopic Colectomy for Colon Cancer |
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Personal genomics for early Breast cancer
How targeted therapy, genetics and personal genomics may prevent local failures and improve Local outcomes.
more... |
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GBC |
PAST ISSUE |
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PERSONALIZED MEDICINE |
CANCER HETEROGENITY REQUIRES
PERSONALIZED CANCER CARE |
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1. BACKGROUND |
Multiple genetic alterations &
signaling pathways network
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Science, Jones, 2008, Pancreatic cancer |
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Science, Wood, 2007, Breast & Colon cancer |
| Genotype-Phenotype map |
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Nature, Rockman, 2008 |
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| 2. Personalized care |
| PERSONALIZED vs COMPARATIVE-EFFECTIVENESS RESEARCH
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N Engl J Med, Garber, 2009 |
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| SYSTEMS BIOLOGY |
| networks modelling
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Nature, Bastiaens, 2009 |
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Molecular Systems Biology, Deisboeck, 2009 |
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Exp Rev Mol Diagn, Roukos, 2009 |
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GBC e - journal 
