Gastric Breast Cancer Network Center

Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

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GBC	CURRENT ISSUE: 2012, (Jan)Vol. 11, Issue 1, pages 1-49
	PERSPECTIVE
	From whole-genome sequencing to gene expression regulation: Perspectives for improving oncological outcomes. Fascinating NGS-based research reveals how mutations, epigenome alterations and deregulated gene expression patterns lead to cancer development. However, prediction of regulatory functional circuits still remains a daunting challenge. Why overcoming such problems is essential for systems translational oncology?
	Whole-genome sequence: from research to clinical practice? NGS-based whole-genome sequencing, exome sequencing and transcriptome sequencing begins to be shifted from research laboratories to medical applications. Is the evidence sufficient for routine use particularly in cancer patients for personalized treatment decision and tailored therapeutics?
	EDITORIAL
	Inhibiting mTOR and VEGF signaling in pancreatic neuroendocrine tumors. Inhibiting mTOR and angiogenesis signaling pathways can improve survival of patients with neuroendocrine tumors in the pancreas
	COMMENTARY
	Gastric cancer recurrence: Is it influenced by laparoscopic gastrectomy
	Laparoscopic Sentinel Node Biopsy in Solid Cancer
	From Asia to Europe : Laparoscopic and robotic gastrectomy for cancer
	NEWS & VIEWS
	The up and down of KRAS testing for personalized colorectal cancer treatment. Although KRAS testing for personalized colorectal cancer treatment has provided initial positive clinical results, a more recent appropriately designed phase 3 randomized trial does not support cetuximab or panitumumab for wild-type KRAS metastatic colorectal cancer.
	Monitoring EGFR plasma levels: Is it a biomarker for colorectal cancer?
	Pancreatic adenocarcinoma: a grand challenge.
	Laparoscopic Right colectomy.
	Economic crisis and laparoscopic surgery.
	REVIEW
	New standard targeted therapy for pancreatic neuroendocrine tumors. Two signal transduction drugs - everolimus, sunitinib - tested in phase 3 trials provide evidence for overall survival improvement in patients with pancreatic neuroendocrine tumors. This review addresses diagnostics, and tumor staging-guided therapeutics.
GBC	PAST ISSUE
	PERSPECTIVE
	Functional Genomics and Chromatin: Why understanding gene expression regulation is essential to revolutionize cancer therapy?
	EDITORIAL
	Novel Techniques in Radiation Therapy
	COMMENTARY
	KRAS mutation testing: Why is it now not recommended for colorectal cancer EGFR inhibitors treatment decision?
	Minimally invasive total mesorectal excision for extraperitoneal rectal cancer: Why patients should seek specialized hospitals and surgeons?
	Field-in-Field Technique as a Treatment of Choice in Tangential Whole Breast Irradiation
	NEWS & VIEWS
	Sigmoid or rectal cancer: do patients benefit from high ligation of inferior mesenteric artery ?
	HER2 status-based selection of gastric cancer patients for trastuzumab treatment.
	Breast cancer risk-reducing surgery and BRCA testing.
	How to prevent or treat hereditary diffuse gastric cancer?
	Peritoneal recurrence: The challenge in gastric cancer treatment and efforts to prevent.
	Total gastrectomy: Preventing hereditary diffuse gastric cancer.
	Assessing resistance to neoadjuvant treatment for breast cancer.
	Cytoreductive Surgery for Ovarian Cancer: Is Splenectomy indicated?
	SPECIAL ARTICLE
	Asymmetric open field-in-field can replace wedged fields in tangential whole breast irradiation
	REVIEW
	Translational advances and challenges for pharmacogenomics-based prescription of drugs.

BREAKTHROUGH PAPERS
	Nature, Green, 2011
	Cell, Hanahan, 2011
	Science, Blaxter, 2010
	Nat Rev Drug Discov, Garzon, 2010
	Science, modENCODE Consortium, 2010
	Cell, Ashworth, 2011
	Nature, de Bono, 2010
	Science, Chaffer, 2011
	Nat Biotechnol, Kelly, 2010
	Lancet, Maughan, 2011
	N Engl J Med, Chapman, 2011
	Nat Biotechnol, Feinberg, 2010
	Nat Biotechnol, Portela, 2010
	EMBO J, van Steensel, 2011
	ΚΛΗΡΟΝΟΜΙΚΟΣ ΚΑΡΚΙΝΟΣ ΜΑΣΤΟΥ - ΩΟΘΗΚΗΣ
Ο ΑΛΓΟΡΙΘΜΟΣ ΤΟΥ ΠΑΝΕΠΙΣΤΗΜΙΟΥ ΙΩΑΝΝΙΝΩΝ Ολοκληρωμένο, 4-βημάτων μοντέλο για εξατομικευμένη κλινική απόφαση : • BRCA θετικό τεστ • BRCA αρνητικό τεστ Πληροφορίες