Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer


Gastric & Breast Cancer
DOI: 10.2122/gbc.2004.0037

REVIEW

P27Kip1 and Gastric Carcinoma

George K Anagnostopoulos MD1, Dimitrios Stefanou MD PhD, Niki J Agnantis MD PhD FRCPath[2]
Abstract
P27Kip1, a cyclin-dependent kinase inhibitor, plays an important role as inhibiting the progression of the cell cycle. Decreased expression of P27Kip1 is associated with high histological grade and aggressiveness of several tumors. Loss of P27Kip1 occurs early during carcinogenesis. Recently, subcellular cytoplasmic localization has also been proposed as a regulatory mechanism of P27Kip1 function. This study reviews all current information about the functions and regulation of p27, its deregulation during gastric carcinogenesis, and summarizes all evidence existing in the literature on the immunoexpression of P27Kip1 in gastric cancer.

Key words: p27, gastric cancer, Helicobacter pylori, prognosis

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Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 22 May 2003