Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer


Gastric & Breast Cancer
DOI: 10.2122/gbc.2002.0005

ORIGINAL ARTICLE
February, 2002

Accurate Prediction of Site-Specific Risk of Recurrence after Curative Surgery for Gastric Cancer

ABSTRACT

TNM-staging according to UICC/AJCC classification accurately predicts overall survival for gastric cancer but provides no information about risks of recurrence. We report here original prospectively documented data of overall and first site-specific recurrence with a median follow-up of 92 months after curative extended (D2) resection for gastric cancer.

A simple classification into three groups based on both pathological serosa-/node status (first group: both negative; second group: either serosa- or node-negative cancer; third group: both positive) demonstrated highly significant differences in multivariate analysis [RR 7.07 (95% CI, 2.36-21.17) and 16.19 (95% CI, 5.76-45.54), of second and third group vs. first group respectively]. The most frequent sites of recurrence were the peritoneum for serosa-positive and distant organs for node-positive/serosa negative cancers whereas the risk of local and/or nodal recurrence was low.

This proposed classification appears to be simple for the introduction into medical practice and potentially useful towards the development of recurrence-oriented preventive target therapies.


Full Text

Comments and questions? Please contact us.

The Gastric Breast Cancer Network Center is owned, published, and copyrighted 2002. All rights reserved.

Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

We subscribe to the HONcode principles of the HON Foundation. Click to verify. We subscribe to the HONcode principles. Verify here.
please, read our policy about privacy and confidentiality of information and transparency of sponsorship

last update: 22 May 2003