Gastric & Breast Cancer
Prediction of Site-Specific Risk of Recurrence after Curative
Surgery for Gastric Cancer
according to UICC/AJCC classification accurately predicts overall
survival for gastric cancer but provides no information about
risks of recurrence. We report here original prospectively documented
data of overall and first site-specific recurrence with a median
follow-up of 92 months after curative extended (D2) resection
for gastric cancer.
A simple classification into three groups based on both pathological
serosa-/node status (first group: both negative; second group:
either serosa- or node-negative cancer; third group: both positive)
demonstrated highly significant differences in multivariate analysis
[RR 7.07 (95% CI, 2.36-21.17) and 16.19 (95% CI, 5.76-45.54),
of second and third group vs. first group respectively]. The most
frequent sites of recurrence were the peritoneum for serosa-positive
and distant organs for node-positive/serosa negative cancers whereas
the risk of local and/or nodal recurrence was low.
This proposed classification appears to be simple for the introduction
into medical practice and potentially useful towards the development
of recurrence-oriented preventive target therapies.
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