& Breast Cancer
in Surgical Decision of BRCA1/BRCA2-Mutation Carriers
advances in genetics of familial breast and ovarian cancer, the
clinical management of women with established mutations in BRCA1
or BRCA2 genes remains controversial. For women who decide for
prophylactic surgery and not for a conservative approach, it is
highly debated whether they are benefited more by a prophylactic
mastectomy rather than a prophylactic oophorectomy. Although BRCA-mutation
carriers are at substantially higher risk for developing breast
cancer rather than ovarian cancer, a medical decision-making is
a major challenge. Penetrance estimates of breast and ovarian
cancer considerably vary and substantially differ between BRCA1
and BRCA2 mutation carriers. This variation is important in decision-making.
Here we balance risks and benefits of these two surgical procedures
regarding cancer risk estimates, effectiveness, morbidity and
quality of life.
and questions? Please contact us.
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