cancer is the end result of a multifactorial, multigenetic,
multistep process. Environmental exposures and genetic factors
have been reported to cause gastric cancer but the debate about
whether environment or heritability plays the principal role
continuous. The knowledge of factors that influence gastric
carcinogenesis is determinant for the development of strategies
effective for prevention and treatment.
the past decades various conditions and risk factors have been
identified to predispose to cancer development. However, now
most clinical and research attention has been focused on Helicobacter
pylori infection, the preneoplastic lesions chronic atrophic
gastritis and intestinal metaplasia, the free-radicals and on
familial gastric cancer predisposition.