Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2007.0070


Prognosis of BRCA and non BRCA mutation carriers
F. Roviello, D.Ziogas

Since there is no abstract we provide the first sentence
In a recent issue of Annals of Surgical Oncology Heemskerk-Getherritsen et al. [1] provide clinical useful data supporting the efficacy of genetic testing and prophylactic mastectomy (PM) in unaffected and affected by breast cancer carriers of mutations in BRCA1 and BRCA2. No breast cancer occurred among 358 BRCA carriers (unaffected women, n = 177; affected, n = 181) after PM in a median follow-up of 4.5 years. However, is it PM the optimum preventive intervention, at the same time as data on other preventive options including prophylactic salpingo-oophorectomy (PBSO) chemoprevention and intensified surveillance have become available?

Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 3 February 2004