Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2009.0096

Published Ahead of Print on January 9, 2009


Cancer Genetic Variation and Systems Biology: New Era for Novel Drugs' Discovery and Personalized Management

Since there is no abstract available we provide the first paragraph

The first entirely sequenced genome for cancer patients is here ( Nature 2008; 456: : 66 ). Most recent sequencing studies analyzing about 20,000 genes in several common solid cancers (Cancer Genome Atlas) showed that in average 60 to 100 genetic alterations are involved in tumorigenesis ( Science 2007: 318:1108 and 2008; 321:1801). Most recently, Genome-wide association (GWA) studies published in Nature, Sciences and N Engl J Med identifying a tremendous number of novel genetic alterations in known or novel loci in common diseases including cancer confirm the theory: solid cancer are highly heterogeneous. This fact meets the plausible explanation of targeted agents, which target a single gene-encoded protein.


Could these major discoveries achieved through new technologies, including next years, next generation, whole-genome sequencing and microarrays be translated into personalized clinical practice saving millions of lives in the next years come?

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Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 9 January 2009