Abstract:

Since there is no abstract, we provide the first paragraph

The idea of the dependence of tumor growth and metastasis on blood vessels was published for the first in the 1970s [1]. Tumor anti-angiogenesis is a rational target for therapy. Although accumulating preclinical evidence supports this hypothesis there is still moderate overall survival benefit in patients with metastatic colorectal and lung cancer, No positive adjuvant trial has reported improved cure by adding anti-angiogenic agents to cytotoxic chemotherapy for any cancer type.