Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2017.0256
Mini Review
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Therapeutic intervention of Hepatic, Billiary and Pancreatic cancer genomes in time and space.
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George Glantzounis, MD, PhD.
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Affiliation: George Glantzounis, Associate Professor of Surgery, Department of Surgery, University Hospital of Ioannina, Ioannina, TK 45110, Greece.
E-mail: gglantzounis@hotmail.com |
Abstract.
Spatiotemporal evolution of Hepatic, Billiary and Pancreatic (HBP) cancers, which represent a major health problem because of their high incidence, metastatic potential and mortality rates [1] could explain extremely complex molecular and mutational landscapes underlying therapeutic resistance and disease relapse. Over the past few years innovative but quite small studies exploring intratumor heterogeneity and circulating genomic subclones provide high expectations to predict and overcome intrinsic and acquired therapeutic resistance [2]. In this article, pioneering solutions to overcome major challenges in effective and sustainable therapeutic interventions are discussed.
(Citation: Gastric & Breast Cancer 2017; 12(1): 13-19)
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Online
ISSN : 1109 - 7647
Print ISSN : 1109 - 7655
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