Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2017.0255
EDITORIAL
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Precision in targeting breast cancer genome. |
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Affiliation: Head of the Breast Unit, Head of 1st Department of Propaedeutic Surgery, University of Athens, Greece.
Tel: +306932524836
E-mail: gzografo@med.uoa.gr |
Abstract
Despite rapid progress in translating molecular pathology into positive phase III randomized controlled trials (RCTs) and clinical therapeutic strategy for breast cancer targeted therapy (trastuzumab, trastuzumab-emtansine, lapatinib, palbociclib) relapse rates remain high.
Conventional single biopsy and breakthrough multiple solid and liquid biopsies for Next-Generation Sequencing (NGS) analysis provide innovative discoveries in the fields of robust biomarkers and early drug development strategy. However, despite advances in intratumor heterogeneity, circulating genomic subclones diversity and their difference with relapsed and metastatic tumors for each individual patient multiple challenges are emerging. This editorial summarizes latest advances and obstacles to reach Precision Oncology for breast cancer.
(Citation: Gastric & Breast Cancer 2017; 12(1): 1-6)
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Online
ISSN : 1109 - 7647
Print ISSN : 1109 - 7655
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