Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0233

EDITORIAL

100 breast cancer genome sequencing: Heterogeneity-based diagnostic and therapeutic perspectives.

Chee-Seng Ku, MD, PhD.

Affiliation: Chee-Seng Ku, Cancer Science Institute of Singapore, National University of Singapore, Singapore.

E-mail: csikcs@nus.edu.sg

Abstract
Genes and mutations involved in breast cancer vary considerable reveals a latest study published in Nature [1]. Applying whole-exome sequencing in primary and metastatic tumors from 100 breast cancer patients, Stephens and colleagues [1] found 73 different combinations of cancer genes. This study reveals a wide genetic heterogeneity and nearly a specific for each patient mutational landscape. What are the consequences of this report on the clinic? How many driver mutations are required for transforming a normal cell to cancer cell? Can this WES-based testing lead to personalized therapeutics?

(Citation: Gastric & Breast Cancer 2012; 11(3): 127-130)

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Online ISSN : 1109 - 7647
Print ISSN : 1109 - 7655

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last update: 4 July 2012