Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0229


Tumor diversity: Implementing NGS into clinic

William CS CHO, MD, PhD.

Affiliation: William CS Cho, Scientific Officer, Department of Clinical Oncology, Queen Elizabeth Hospital, Room 1305, 13/F, Block R, 30 Gascoigne Road, Kowloon, Hong Kong.


The hypothesis of genetic and genomic diversity in malignant tumors is now confirmed by recent studies using next-generation sequencing (NGS) technologies. Heterogeneity is now assessed not only among different breast cancer patients with same tumor type, stage and conventional clinicopathologic features but also for individual renal cancer patients with substantial differences in mutational landscape when NGS0based sequencing of distinct separate biopsies from the same tumor. These findings published over the last few months in Nature and NEJM may change the way of anticancer drugs selection and decision-making by multidisciplinary teams with expertise in analysis and interpretation of genomic data in clinical genomic medicine era. Here I discuss potential diagnostic, prognostic and therapeutic applications and challenges of genome sequence in patients with solid cancer.

(Citation: Gastric & Breast Cancer 2012; 11(3): 121-126)



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last update: 27 June 2012