Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0224


‘Sequence everything' strategy in the clinical cancer genome era .

Ioannis Georgiou, PhD.

Affiliation: (IG), from the Laboratory of Human Reproductive Genetics, Department of Obstetrics and Gynaecology , Medical School, University of Ioannina, GR 451 10 Ioannina, Greece.

The free falling costs and the validity of data derived from next-generation sequencing (NGS) technologies have shifted the efforts from research setting to the clinical setting with respect to cancer causal mutations identification and functional genomics. The “sequencing everything” approach by applying NGS with whole-genome sequencing, whole-exome sequencing and transcriptome analysis along with gene expression profiling has recently been reported in two patients with colorectal cancer and melanoma respectively. Whether such a high-throughput technology-based integrative approach cab provide clinically robust information to improve decision making by tailoring a more effective targeted therapy is discussed here.

(Citation: Gastric & Breast Cancer 2011; 11(2): 65-71)



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last update: 23 April 2012