Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2012.0222


Genome-based diagnostics and therapeutics in personalized cancer therapy: Can the challenges be overcome?

J. Ajani, MD, PhD.


Since there is no abstract available we provide the first paragraph.
With isolated success trastuzumab, imatinib, vemurafenib-, the current generation of targeted drugs provides limited benefit for cancer patients. Evidence from phase 3 randomized trials suggests mostly progression-free survival benefit without a true overall survival prolongation. The advent of high-throughput technologies and advances in systems computational biology shape now high expectations for the next-generation cancer-targeted drugs and biomarkers. This new era of personalized medicine raises hope for individual tumor-heterogeneity-based implementation of targeted drugs. Which are the challenges and how could be possible to overcome therapeutic resistance of cancer cells and to increase cancer therapy efficacy and improve oncological outcomes?

(Citation: Gastric & Breast Cancer 2011; 11(2): 53-57)



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last update: 23 April 2012