ABSTRACT
The advent of next-generation sequencing (NGS) technologies has provided unprecedented powerful unbiased research on genomics, transcriptomics, epigenomics and chromatin remodeling. This characterization of these complex interacting systems provides the first steps towards understanding gen expression regulatory networks. The ability of NGS device for whole-genome sequencing for identifying all kinds of mutations –SNPs, insertions, deletions, copy-number changes, translocations- simultaneously, faster, cheaper and more accurate than traditional Sanger DNA sequencing has made it very popular. The evolution of this massively parallel sequencing platform is so rapid that the first applications in clinical medicine and cancer treatment have already been reported. In this perspective article, the potential prescription of NGS-based exome and whole-genome in routine clinical practice is discussed.

(Citation: Gastric & Breast Cancer 2012; 11(1): 7-12)

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