Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2011.0165


Breast cancer biomarker: Advances, validation and novel discoveries.

George Zografos M.D, PhD.

Affiliation: Head of the Breast Unit, Head of 1st Department of Propaedeutic Surgery, University of Athens, Greece.

Tel: +306932524836


In contrast to most other major solid cancers, progress in the development, validation and clinical use of biomarkers in the prevention and treatment setting of breast cancer is impressive. In the field of prevention, the lives of women at very high risk of developing hereditary breast ovarian cancer syndrome can be saved by BRCA testing, before the clinical evidence of the syndrome, and with appropriate prophylactic surgery. In the field of treatment after diagnosis, estrogen-receptor (ER) and HER2 overexpression have established as biomarkers for tailoring tamoxifen and aromatase inhibitors in ER+ tumors and trastuzumab for HER+ disease. Despite these advances, a remarkable percentage of ER+/HER+ patients recur while for ER-/HER2-negative disease, no robust additional marker and targeted therapy exists, apart of chemotherapy. As a result recurrence and treatment failure is considerable and still the rate of patients who die from the disease still remains high.

(Citation: Gastric & Breast Cancer 2011; 10(2): 123-130)

This article is 8 pages long, and includes 1 table



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Online ISSN : 1109 - 7647
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last update: 17 March 2011