Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2011.0159

OPINION

miRNAs gene expression regulation and their role in cancer prediction and therapy.

Peter M. Schlag, M.D.

Affiliation: Charité-Universitätsmedizin Berlin, Campus Mitte, Klinik für Allgemein-Visceral-, Gefäss- und Thoraxchirurgie, Charitéplatz 1, 10117, Berlin, Germany.

E-mail : schlag@rrk.charite-buch.de

ABSTRACT
MicroRNAs (miRNAs) have a crucial role in the regulation of gene expression patterns. Silencing of tumor-suppressor genes and reactivation of oncogenic retroviruses are involved during cancer development and progression. Therefore, specific miRNAs that are upregulated or downregulated in certain cancer types and can be measured thanks to latest high-throughput screening technology provide exciting new avenues for cancer research. Here, it is described how miRNA translational research findings could be incorporated into clinic, and the challenges for their application as biomarkers, or new therapeutic targets in cancer.

(Citation: Gastric & Breast Cancer 2011; 10(2): 79-84)

This article is 6 pages long, and includes 1 figure

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Online ISSN : 1109 - 7647
   Print ISSN : 1109 - 7655

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last update: 11 March 2011