Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

Gastric & Breast Cancer e-journal
DOI: 10.2122/gbc.2011.0156


Cancer prevention and prophylactic surgery: Standards and GWAS-based perspectives.

Christos S. Katsios, M.D.

Affiliation: Christos Katsios, Associate Professor of Surgery, Department of Surgery, University Hospital of Ioannina, Ioannina, TK 45110, Greece.

Tel: +2651099696


Cancer is the leading cause of mortality in economically developed countries and given its extreme complexity the major threat of human in the future. Primary prevention represents a great goal of biomedical science to reduce morbidity and mortality from malignant disease. Risk-reducing surgery is safe and effective to save the lives of individuals at risk for the development of hereditary cancer syndromes including breast-ovarian, colorectal, and gastric cancer. However, these syndromes are rare and cancer risk prediction is ~75% reflecting a 25% of mutation carriers who undergoing unnecessary prophylactic surgery and experience substantial diverse effects.

Here, it is discussed the advantages and limitations of prophylactic surgery in individuals selected on the basis of family history and genetic testing ( BRCA1/2, mismatch-repair genes , CDH1 ). Moreover, it is described the opportunities and challenges of genome-wide association studies to identify persons at high risk of cancer expanding therefore the indications of preventive surgery in the future.

(Citation: Gastric & Breast Cancer 2011; 10(2): 116-122)

This article is 7 pages long, and includes 1 table



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Online ISSN : 1109 - 7647
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last update: 17 March 2011