Current
best practices and rationalistic perspectives in causation-based
prevention, early detection and multidisciplinary treatment
of breast and gastric cancer
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PERSPECTIVE |
| Gene-Expression
Profile: The Future In The Outcome Prediction And Treatment Of
Breast Cancer |
| Abstract |
| The
malfunctioning of specific genes drives probably the development
and progression of neoplastic disease. Indeed, recent studies
using microarray analysis provide evidence that breast cancer
tumors can be classified according to their gene-expression profiling
into subgroups with poor prognosis and good prognosis. These works
represent a considerable advance in the clinical application of
microarray technology. |
| The
fascinating of these studies is that the DNA-microarray data predict
the outcome -overall survival and distant metastases- much better
than such classic prognostic indicators as nodal status, grade,
stage, and estrogen-receptor status. |
| The
finding that the genetic signature of a breast cancer is strongly
associated with outcome independently of nodal status has important
biologic implications and may change the current therapeutic strategy
regarding clinical decision making about adjuvant chemotherapy
in some individuals who at present either overtreated or undertreated.
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