of Epithelial Cancer: The Challenge for the 21st Century
H. Roukos, MD, Michael Fatouros, MD, Dimitrios Giannakis,
MD, Ioannis Arampatzis, Evangelos Paraskevaidis, MD,
Nikolaos Sofikitis, MD and Niki J. Agnantis, MD, PhD
apparent declines in incidence and overall mortality
rates from cancer,1 both remain at near all time highs.
These trends pale in comparison with the dramatic
declines for heart disease and stroke. If current
trends continue, cancer is expected to be the leading
cause of death in the United States (US) by 2010.
A future pandemic of new cancer cases in the USA could
be resulted from the aging of the population and the
high proportion of new cases in older persons (>
60 years).[3-5] The World Health Organization estimates
that worldwide the number of new cancer cases will
be increased from 9 million new cases annually now
to 20 million cancer cases annually by 2020 and cancer
deaths from 5 million to more than 10 million. Cancer
prevention provides excited potential to reduce incidence
and cancer mortality.