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CURRENT ISSUE: 2012, (Apr)Vol. 11, Issue 2, pages 50-107 |
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EDITORIAL |
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Transcriptome mapping: ER-binding sites dynamics reveal new strategy for breast cancer biomarkers
Despite thousands of enthusiastic biomarkers reports, therapeutic response prediction before therapy initiation still remains a daunting challenge. Revolutionary genome-wide mapping technologies (ChIP-seq) provide unprecedented ability for transcriptome analysis. With the dynamic of ER-binding sites that has more recently reported in Nature , a new epoch of translational transcriptome mapping-based biomarkers has been launched. |
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Genome-based diagnostics and therapeutics in personalized cancer therapy: Can the challenges be overcome?
Although targeting cancer with antibodies and/or kinase inhibitors can improve oncological outcomes, resistance still remains a grand challenge. How could NGS technologies and systems computational biology advances result in overcoming resistance and therapeutic failure? |
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PERSPECTIVE |
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‘Sequence everything' strategy in the clinical cancer genome era
As we are shifting from research to clinical whole-genome sequencing and whole-exome sequencing for cancer clinical practice, which are the challenges and how can we overcome anticancer drugs resistance and therapeutic failure in the era of personalized cancer therapy?
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Tumor heterogeneity-based personalized oncology
Next-generation sequencing technologies provide the power to detect most genetic mutations and epigenetic alterations driving cancer initiation and metastasis. Is such identification underlying each individual patient sufficient to reach personalized oncological therapy or further understanding of deregulated signalling pathways network and cellular dysfunction in cancer cells is essential for achieving pragmatic improvements in cancer treatment?
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NEWS & VIEWS |
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REVIEW |
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Management of advanced non-clear cell renal carcinoma.
Renal cell carcinoma (RCC) comprises 2-3% of all malignancies. Approximately 90% of renal tumors are RCCs, and 15% of these are non-clear cell tumors, which include papillary, chromophobe, Bellini duct (collecting duct) and sarcomatoid tumors.
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PAST ISSUE |
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PERSPECTIVE |
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EDITORIAL |
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COMMENTARY |
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NEWS & VIEWS |
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| Economic crisis and laparoscopic surgery. |
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REVIEW |
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BREAKTHROUGH PAPERS |
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Nature,
Green, 2011 |
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Cell,
Hanahan, 2011 |
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Science,
Blaxter, 2010 |
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Nat Rev Drug Discov,
Garzon, 2010 |
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Science,
modENCODE Consortium, 2010 |
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Cell,
Ashworth, 2011 |
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Nature,
de Bono, 2010 |
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Science,
Chaffer, 2011 |
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Nat Biotechnol, Kelly, 2010 |
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Lancet,
Maughan, 2011 |
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N Engl J Med, Chapman, 2011 |
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Nat Biotechnol, Feinberg, 2010 |
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Nat Biotechnol, Portela, 2010 |
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EMBO J,
van Steensel, 2011 |
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ΚΛΗΡΟΝΟΜΙΚΟΣ ΚΑΡΚΙΝΟΣ ΜΑΣΤΟΥ - ΩΟΘΗΚΗΣ |
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Ολοκληρωμένο, 4-βημάτων μοντέλο για εξατομικευμένη κλινική απόφαση :
BRCA θετικό τεστ
BRCA αρνητικό τεστ
Πληροφορίες |
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