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GBC |
CURRENT ISSUE: 2010, Volume 9, Issue 3 |
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Reversing Cancer and Ageing: Multiple Personal Genomes, Life Complexity and Myriad Clinical Challenges
Ten years after, “big” science has provided ~ 20 published and ~ 200 unpublished complete human and cancer genomes sequence. But yet clinical applications are minimal. Abstract |
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Cetuximab, panitumumab and bevacizumab resistance in colorectal cancer: Are molecular networks the solution?
There has been enthusiasm that the addition of the targeted agents cetuximab, panitumumab and bevacizumab to chemotherapy can improve overall survival (OS) of patients with colorectal cancer (CRC). more... |
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Comparative-effectiveness research and personalized medicine: Trends and debate
Comparative-effectiveness research (CER) is the current gold standard for improving health care. New products including drugs, medical devices, diagnostics, biomarkers and therapeutics should be proven more effective and safe more... |
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Evidence-based laparoscopic surgery for low rectal cancer
Laparoscopic low anterior resection can improve outcomes of patients with rectal cancer. more... |
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Trastuzumab for small HER2-positive breast cancer? Uncertainty and new research directions
Although cure is achievable in small breast cancer, a subgroup of women faces a recurrence risk. This article discusses advances and limitations in predicting this high-risk group, whether trastuzumab for small, HER2-positive tumors can reduce recurrence risk. more... |
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Intellectual innovation and new technology in surgical oncology
The advent of new technologies has revolutionized biomedical research. But clinical implications for improving health are hard. more... |
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NEWS & VIEWS |
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Western challenges with esophagectomy and follow-up
Standardizing colorectal cancer treatment |
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Selection and identification of DNA aptamers to gastric cancer cell SGC-7901
Gastric cancer is one of the most deadly cancers in the world. Early diagnosis and treatment are effective for improving the survival rate of gastric cancer, but there is a shortage of specific probes for molecular signatures. more... |
GBC |
PAST ISSUE |
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The new era of systems medicine and cancer networks
Why the present generation of biomarkers and biologic agents, with a few exceptions, has been failed? more...
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Breast cancer: Trastuzumab for HER2-positive patients and molecular systems approach.
Although trastuzumab represents the triumph of molecular translational research, yet many women with early breast cancer face a high risk of recurrence and death. more...
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Advances in laparoscopic gastrectomy for early and advanced resectable gastric cancer
Totally laparoscopic D2 gastrectomy is a highly demanding procedure. more... |
 
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NEWS & VIEWS: Endoscopic submucosal dissection for gastric tube cancer after esophagectomy |
| NEWS & VIEWS: Challenges and expectations for novel biologics discovery in HER2-negative breast cancer |
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Decision-making treatment for early breast cancer and future perspectives
The commercialization of 70-gene signature (MammaPrint) ® and 21-gene assay (Oncotype DX) ® and new results of isolated tumor cells in lymph nodes have arisen optimism. more... |
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PERSONALIZED MEDICINE |
CANCER HETEROGENITY REQUIRES
PERSONALIZED CANCER CARE |
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1. BACKGROUND |
Multiple genetic alterations &
signaling pathways network
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Science, Jones, 2008, Pancreatic cancer |
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Science, Wood, 2007, Breast & Colon cancer |
| Genotype-Phenotype map |
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Nature, Rockman, 2008 |
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| 2. Personalized care |
| PERSONALIZED vs COMPARATIVE-EFFECTIVENESS RESEARCH
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N Engl J Med, Garber, 2009 |
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| SYSTEMS BIOLOGY |
| networks modelling
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Nature, Bastiaens, 2009 |
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Molecular Systems Biology, Deisboeck, 2009 |
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Exp Rev Mol Diagn, Roukos, 2009 |
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Ann Surg, Roukos, 2009 |
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Mol Syst Biol.
2009. Snyder M |
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Mol Syst Biol. 2007. Lemberger T |
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GBC e - journal 
