Gastric Breast Cancer Network Center

Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

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LAST UPDATE : January 30, 2010		GBCNC Web Site		Associate Editor: D. Trichopoulos, MD, Harvard/ U.S		FOCUS

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GBC

CURRENT ISSUE: 2010, Volume 9, Number 1

PERSPECTIVE

Systems medicine for a next-generation of biomarkers and drugs: Changing poor cancer outcomes.

Intracellular signaling pathways network-based development of biomarkers and biologic agents might revolutionize the future. These biologics may overcome current resistance reducing recurrence and mortality rates. How realistic is this approach? more...

EDITORIAL

Why Gastric and Breast Cancer Journal ? CDH1 and HER2
Current evidence suggests a relationship in both, prevention setting (CDH1) and treatment setting (HER2-positive, trastuzumab) of breast cancer and gastric cancer comfirmining our own initiative to create the Gastric & Breast Cancer journal more...

NEWS & VIEWS: Nipple-Sparing Mastectomy

COMMENTARY: Open or laparoscopic colorectal cancer resection: standardization and lymph nodes retried

COMMENTARY: Low anterior rectal resection for rectal cancer: Why laparoscopic or robotic surgery may improve outcomes?

COMMENTARY: Laparoscopic D2 gastrectomy: A new horizon even in the West

REVIEW

Very early (T1a,bN0) breast cancer: HER2 and algorithmic approach to predict and treat patients at high recurrence risk
A few women among those with very early breast cancer recur and die from the disease. How can we identify these high-risk patients before treatment and how to treat them in order to save their lives? more...

GBC

PAST ISSUE

PERSPECTIVE

Personalized Molecular cancer-targeted therapy

Why novel causal network-based biomarkers and new targeted agents are needed and how to overcome challenges. more...

EDITORIAL: Anti-VEGF Agents (Bevacizumab) Limitations

EDITORIAL: Impact of genetics and genomics in breast cancer surgery

REVOLUTION IN SURGERY

Laparoscopic & robotic approaches change oncological practice
Improving dramatically quality of life. Butvwhat are the risks?

EDITORIAL: New era in cancer surgical treatment

NEWS & VIEWS: Rectal cancer resection

NEWS & VIEWS: Laparoscopic Colectomy for Colon Cancer

Personal Genetics and impact on breast surgeon

REVIEW

Personal genomics for early Breast cancer
How targeted therapy, genetics and personal genomics may prevent local failures and improve Local outcomes.

	ΚΛΗΡΟΝΟΜΙΚΟΣ ΚΑΡΚΙΝΟΣ ΜΑΣΤΟΥ - ΩΟΘΗΚΗΣ
Ο ΑΛΓΟΡΙΘΜΟΣ ΤΟΥ ΠΑΝΕΠΙΣΤΗΜΙΟΥ ΙΩΑΝΝΙΝΩΝ Ολοκληρωμένο, 4-βημάτων μοντέλο για εξατομικευμένη κλινική απόφαση : • BRCA θετικό τεστ • BRCA αρνητικό τεστ Πληροφορίες

PERSONALIZED MEDICINE

CANCER HETEROGENITY REQUIRES
PERSONALIZED CANCER CARE

1. BACKGROUND

Multiple genetic alterations & signaling pathways network
	Science, Jones, 2008, Pancreatic cancer
	Science, Wood, 2007, Breast & Colon cancer
Genotype-Phenotype map
	Nature, Rockman, 2008

2. Personalized care
PERSONALIZED vs COMPARATIVE-EFFECTIVENESS RESEARCH
	N Engl J Med, Garber, 2009

SYSTEMS BIOLOGY
networks modelling
	Nature, Bastiaens, 2009
	Molecular Systems Biology, Deisboeck, 2009
	Exp Rev Mol Diagn, Roukos, 2009
	Ann Surg, Roukos, 2009
	Mol Syst Biol. 2009. Snyder M
	Mol Syst Biol. 2007. Lemberger T