Gastric Breast Cancer Network Center

Current best practices and rationalistic perspectives in causation-based prevention, early detection and multidisciplinary treatment of breast and gastric cancer

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EDITOR - IN - CHIEF

Dimitrios H. Roukos, MD

Associate Professor, Surgical Oncology Research Unit
Biobank Personalized Cancer Management Leader
Translational Research Leader in
European Network of Excellence (EUNE) for Gastric Cancer
Ioannina University School of Medicine
451 10 Ioannina , Greece
T: +30 26510 97423, F: +30 26510 97094
email: droukos@cc.uoi.gr
Search for items in ISI Web of Science or PubMed by Roukos D /

Dr. D. Roukos, studied Medicine at the University of Athens and specialized in general Surgery at the J.W.Goethe-University Hospital in Frankfurt a.M., Germany, where he received the title Dr. med. He moved back to Greece and since 1990 works at the Ioannina University School of Medicine.

Current Research Activity	Human genetic variation-based research including quantitative genetics and genome-wide association studies, and integrated models to predict genotypic-phenotypic variation in cancer. Potential implications of systems biology in personalized management of gastric, breast and other solid cancers.
Goal	Improving clinical outcomes of patients by translating cutting-edge research into evidence-based clinical practice

New concepts, models, algorithms

Year

Papers for the first time

Author(s) – Journal.

2009

Assessing both genetic variation (SNPs/CNVs) and gene-environment interactions may lead to personalized gastric cancer prevention .

Roukos DH. Expert Rev Mol Diagn 2009; 9(1): 1-6.

2008

Genetics and genome-wide association studies: surgery-guided algorithm and promise for future breast cancer personalized surgery.

Roukos DH. Expert Rev Mol Diagn 2008 Sept; 8(5): 587–597.

2008

Innovative genomic-based model for personalized treatment of gastric cancer: integrating current standards and new technologies.

Roukos DH. Expert Rev Mol Diagn 2008; 8(1): 29-39.

2007

Individualized preventive and therapeutic management of hereditary breast ovarian cancer .

Roukos DH et al. Nat Clin Pract Oncol 2007; 4 (10) : 578–590

1998

Evidence of survival benefit of extended (D2) lymphadenectomy in western patients with gastric cancer based on a new concept : a prospective long-term follow-up study.

Roukos DH, t al. Surgery. 1998 ; 123(5):573-8.

Benchmarks

1998 -
today

INVITED PAPERS – INVITED SPEAKER (International Sccientific meetings)

• Editorial (17), perspectives, reviews.

• KEYNOTE PRESENTATIONS , Lectures in World Congresses and International Meetings (26).

Citations: > 1.300, Hirsch factor: h=25 (~16/per article).

PERSONALIZED CANCER MANAGEMENT ARTICLES

	Assessing both genetic variation (SNPs/CNVs) and gene-environment interactions may lead to personalized gastric cancer prevention. Roukos DH. Expert Rev Mol Diagn . 2009 Jan;9(1):1-6. No abstract available.

	Genetics and genome-wide association studies: surgery-guided algorithm and promise for future breast cancer personalized surgery. Roukos DH. Expert Rev Mol Diagn . 2008 Sep;8(5):587-97.

	Genomics and challenges toward personalized breast cancer local control. Roukos DH, Lykoudis E, Liakakos T. J Clin Oncol . 2008 Sep 10;26(26):4360-1; author reply 4361-2. No abstract available.

	Personal Genomics and Genome-Wide Association Studies: Novel Discoveries but Limitations for Practical Personalized Medicine. Roukos DH. Ann Surg Oncol . 2008 Aug 23. [Epub ahead of print] No abstract available.

	Breast-cancer stromal cells with TP53 mutations. Roukos DH. N Engl J Med . 2008 Apr 10;358(15):1636; author reply 1636. No abstract available.

	Identifying and preventing high-risk gastric cancer individuals with CDH1 mutations. Ziogas D, Baltogiannis G, Fatouros M, Roukos DH. Ann Surg . 2008 Apr;247(4):714-5; author reply 715-6. No abstract available.

	Linking contralateral breast cancer with genetics. Roukos DH. Radiother Oncol . 2008 Feb;86(2):139-41. Epub 2008 Jan 30. No abstract available.

	Innovative genomic-based model for personalized treatment of gastric cancer: integrating current standards and new technologies. Roukos DH. Expert Rev Mol Diagn . 2008 Jan;8(1):29-39. Review.

	Prognosis of breast cancer in carriers of BRCA1 and BRCA2 mutations. Roukos DH. N Engl J Med . 2007 Oct 11;357(15):1555-6; author reply 1556. No abstract available.

	Individualized preventive and therapeutic management of hereditary breast ovarian cancer syndrome. Roukos DH, Briasoulis E. Nat Clin Pract Oncol . 2007 Oct;4(10):578-90. Review.

	Molecular genetic tools shape a roadmap towards a more accurate prognostic prediction and personalized management of cancer. Roukos DH, Murray S, Briasoulis E. Cancer Biol Ther . 2007 Mar;6(3):308-12. Epub 2007 Mar 9. Review.